Dr. Mario

Dr. Mario is a puzzle game developed and published by Nintendo for the NES and Game Boy in 1990. Mario, dressed as a doctor, drops two-coloured capsules into a bottle full of viruses, and lining up four of the same colour clears them.

Players pick a virus level, a speed and one of two songs, Fever or Chill. A two-player mode sends extra capsules to the opponent when combos are cleared.

A native PC port exists: DrMarioNesRecomp, a static recompilation by mstan with separate USA and European builds.